Optogenetics is widely used to study the effects of neural circuit manipulation on behavior. However, the paucity of causal inference methodological work on this topic has resulted in analysis conventions that discard information, and constrain the scientific questions that can be posed. To fill this gap, we introduce a nonparametric causal inference framework for analyzing "closed-loop" designs, which use dynamic policies that assign treatment based on covariates. In this setting, standard methods can introduce bias and occlude causal effects. Building on the sequentially randomized experiments literature in causal inference, our approach extends history-restricted marginal structural models for dynamic regimes.

Despite significant progress in robotics and embodied AI in recent years, deploying robots for long-horizon tasks remains a great challenge. Majority of prior arts adhere to an open-loop philosophy and lack real-time feedback, leading to error accumulation and undesirable robustness. A handful of approaches have endeavored to establish feedback mechanisms leveraging pixel-level differences or pre-trained visual representations, yet their efficacy and adaptability have been found to be constrained. Inspired by classic closed-loop control systems, we propose CLOVER, a closed-loop visuomotor control framework that incorporates feedback mechanisms to improve adaptive robotic control. CLOVER consists of a text-conditioned video diffusion model for generating visual plans as reference inputs, a measurable embedding space for accurate error quantification, and a feedback-driven controller that refines actions from feedback and initiates replans as needed.

In an era marked by the rapid scaling of foundation models, autonomous driving technologies are approaching a transformative threshold where end-to-end autonomous driving (E2E-AD) emerges due to its potential of scaling up in the data-driven manner. However, existing E2E-AD methods are mostly evaluated under the open-loop log-replay manner with L2 errors and collision rate as metrics (e.g., in nuScenes), which could not fully reflect the driving performance of algorithms as recently acknowledged in the community. For those E2E-AD methods evaluated under the closed-loop protocol, they are tested in fixed routes (e.g., Town05Long and Longest6 in CARLA) with the driving score as metrics, which is known for high variance due to the unsmoothed metric function and large randomness in the long route. Besides, these methods usually collect their own data for training, which makes algorithm-level fair comparison infeasible. To fulfill the paramount need of comprehensive, realistic, and fair testing environments for Full Self-Driving (FSD), we present Bench2Drive, the first benchmark for evaluating E2E-AD systems' multiple abilities in a closed-loop manner.

The use of soft and compliant manipulators in marine environments represents a promising paradigm shift for subsea inspection, with devices better suited to tasks owing to their ability to safely conform to items during contact. However, limitations driven by material characteristics often restrict the reach of such devices, with the complexity of obtaining state estimations making control non-trivial. Here, a detailed analysis of a 1m long compliant manipulator prototype for subsea inspection tasks is presented, including its mechanical design, state estimation technique, closed-loop control strategies, and experimental performance evaluation in underwater conditions. Results indicate that both the configuration-space and task-space controllers implemented are capable of positioning the end effector to desired locations, with deviations of <5% of the manipulator length spatially and to within 5^{o} of the desired configuration angles. The manipulator was also tested when subjected to various disturbances, such as loads of up to 300g and random point disturbances, and was proven to be able to limit displacement and restore the desired configuration. This work is a significant step towards the implementation of compliant manipulators in real-world subsea environments, proving their potential as an alternative to classical rigid-link designs.

End-to-end autonomous driving research currently faces a critical challenge in bridging the gap between open-loop training and closed-loop deployment. Current approaches are trained to predict trajectories in an open-loop environment, which struggle with quick reactions to other agents in closed-loop environments and risk generating kinematically infeasible plans due to the gap between open-loop training and closed-loop driving. In this paper, we introduce Hydra-NeXt, a novel multi-branch planning framework that unifies trajectory prediction, control prediction, and a trajectory refinement network in one model. Unlike current open-loop trajectory prediction models that only handle general-case planning, Hydra-NeXt further utilizes a control decoder to focus on short-term actions, which enables faster responses to dynamic situations and reactive agents. Moreover, we propose the Trajectory Refinement module to augment and refine the planning decisions by effectively adhering to kinematic constraints in closed-loop environments. This unified approach bridges the gap between open-loop training and closed-loop driving, demonstrating superior performance of 65.89 Driving Score (DS) and 48.20% Success Rate (SR) on the Bench2Drive dataset without relying on external experts for data collection. Hydra-NeXt surpasses the previous state-of-the-art by 22.98 DS and 17.49 SR, marking a significant advancement in autonomous driving. Code will be available at https://github.com/woxihuanjiangguo/Hydra-NeXt.

Multi-agent reinforcement learning is a challenging and active field of research due to the inherent nonstationary property and coupling between agents. A popular approach to modeling the multi-agent interactions underlying the multi-agent RL problem is the Markov Game. There is a special type of Markov Game, termed Markov Potential Game, which allows us to reduce the Markov Game to a single-objective optimal control problem where the objective function is a potential function. In this work, we prove that a multi-agent collaborative field coverage problem, which is found in many engineering applications, can be formulated as a Markov Potential Game, and we can learn a parameterized closed-loop Nash Equilibrium by solving an equivalent single-objective optimal control problem. As a result, our algorithm is 10x faster during training compared to a game-theoretic baseline and converges faster during policy execution.

The combination of LLM agents with external tools enables models to solve complex tasks beyond their knowledge base. Human-designed tools are inflexible and restricted to solutions within the scope of pre-existing tools created by experts. To address this problem, we propose ATLASS, an advanced tool learning and selection system designed as a closed-loop framework. It enables the LLM to solve problems by dynamically generating external tools on demand. In this framework, agents play a crucial role in orchestrating tool selection, execution, and refinement, ensuring adaptive problem-solving capabilities. The operation of ATLASS follows three phases: The first phase, Understanding Tool Requirements, involves the Agents determining whether tools are required and specifying their functionality; the second phase, Tool Retrieval/Generation, involves the Agents retrieving or generating tools based on their availability; and the third phase, Task Solving, involves combining all the component tools necessary to complete the initial task. The Tool Dataset stores the generated tools, ensuring reusability and minimizing inference cost. Current LLM-based tool generation systems have difficulty creating complex tools that need APIs or external packages. In ATLASS, we solve the problem by automatically setting up the environment, fetching relevant API documentation online, and using a Python interpreter to create a reliable, versatile tool that works in a wider range of situations. OpenAI GPT-4.0 is used as the LLM agent, and safety and ethical concerns are handled through human feedback before executing generated code. By addressing the limitations of predefined toolsets and enhancing adaptability, ATLASS serves as a real-world solution that empowers users with dynamically generated tools for complex problem-solving.

Integrating large language models (LLMs) into autonomous driving has attracted significant attention with the hope of improving generalization and explainability. However, existing methods often focus on either driving or vision-language understanding but achieving both high driving performance and extensive language understanding remains challenging. In addition, the dominant approach to tackle vision-language understanding is using visual question answering. However, for autonomous driving, this is only useful if it is aligned with the action space. Otherwise, the model's answers could be inconsistent with its behavior. Therefore, we propose a model that can handle three different tasks: (1) closed-loop driving, (2) vision-language understanding, and (3) language-action alignment. Our model SimLingo is based on a vision language model (VLM) and works using only camera, excluding expensive sensors like LiDAR. SimLingo obtains state-of-the-art performance on the widely used CARLA simulator on the Bench2Drive benchmark and is the winning entry at the CARLA challenge 2024. Additionally, we achieve strong results in a wide variety of language-related tasks while maintaining high driving performance.

Medical imaging quality control (QC) is essential for accurate diagnosis, yet traditional QC methods remain labor-intensive and subjective. To address this challenge, in this study, we establish a standardized dataset and evaluation framework for medical imaging QC, systematically assessing large language models (LLMs) in image quality assessment and report standardization. Specifically, we first constructed and anonymized a dataset of 161 chest X-ray (CXR) radiographs and 219 CT reports for evaluation. Then, multiple LLMs, including Gemini 2.0-Flash, GPT-4o, and DeepSeek-R1, were evaluated based on recall, precision, and F1 score to detect technical errors and inconsistencies. Experimental results show that Gemini 2.0-Flash achieved a Macro F1 score of 90 in CXR tasks, demonstrating strong generalization but limited fine-grained performance. DeepSeek-R1 excelled in CT report auditing with a 62.23\% recall rate, outperforming other models. However, its distilled variants performed poorly, while InternLM2.5-7B-chat exhibited the highest additional discovery rate, indicating broader but less precise error detection. These findings highlight the potential of LLMs in medical imaging QC, with DeepSeek-R1 and Gemini 2.0-Flash demonstrating superior performance.

Large Language Models (LLMs) exhibit remarkable capabilities in the hierarchical decomposition of complex tasks through semantic reasoning. However, their application in embodied systems faces challenges in ensuring reliable execution of subtask sequences and achieving one-shot success in long-term task completion. To address these limitations in dynamic environments, we propose Closed-Loop Embodied Agent (CLEA) -- a novel architecture incorporating four specialized open-source LLMs with functional decoupling for closed-loop task management. The framework features two core innovations: (1) Interactive task planner that dynamically generates executable subtasks based on the environmental memory, and (2) Multimodal execution critic employing an evaluation framework to conduct a probabilistic assessment of action feasibility, triggering hierarchical re-planning mechanisms when environmental perturbations exceed preset thresholds. To validate CLEA's effectiveness, we conduct experiments in a real environment with manipulable objects, using two heterogeneous robots for object search, manipulation, and search-manipulation integration tasks. Across 12 task trials, CLEA outperforms the baseline model, achieving a 67.3% improvement in success rate and a 52.8% increase in task completion rate. These results demonstrate that CLEA significantly enhances the robustness of task planning and execution in dynamic environments.